The seven-year-old Gazan boy, identified as Ali al-Awour, died on Saturday, said a spokesman for the Palestinian health services.
The boy was injured in a Wednesday airstrike in Beit Lahia, in the northern part of the besieged enclave, which also killed his uncle.
The boy was passing by on foot as an Israeli aircraft fired a rocket at his uncle, on a motorbike with another man who got wounded.
The Israeli military frequently targets Palestinians particularly along the border with the besieged enclave.
Over 160 Palestinians, including women and children, were killed and about 1,200 others were injured in the Israel’s eight-day offensive on the coastal enclave, which ended on November 21, 2012.
Gaza has been blockaded since June 2007, a situation that has caused a decline in the standards of living, unprecedented levels of unemployment, and unrelenting poverty.
The apartheid regime of Israel denies about 1.7 million people in Gaza their basic rights, such as freedom of movement, jobs that pay proper wages, and adequate healthcare and education.